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Washington University Experience | DEVELOPMENTAL MALFORMATIONS | Granule cell Aplasia | 1A3 Aplasia, Granule Cell (Case 1) H&E 2A

The low power examination shows wholesale loss of granule cells and a patchy eosinophilia within the molecular layer. Higher magnification confirms the marked loss of granule cells and relative preservation of Purkinje cells. The granular cell layer contains large acellular aggregates which appear to arise from the apical branches of the Purkinje cell arbors. (H&E)

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