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Washington University Experience | DEVELOPMENTAL MALFORMATIONS | Hemimegalencephaly | 8B2 FCD, type IIA (Case 9) H&E 9
8B2-4 Markedly abnormal neurons have large size, a more spherical shape compared to pyramidal, increased and clumped Nissl substance, abnormal dendritic arborization, abnormal clearing of nuclei, frequent macro-nucleoli, and rare binucleation. Large dysplastic and dysmorphic neurons are also present in layer 1, as well as in the subcortical white matter; the latter resulting in multifocal blurring of gray-white junction.
