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Washington University Experience | DEVELOPMENTAL MALFORMATIONS | Microcephaly-Micrencephaly | 3A0 Case 3 History
This patient was a 44 year old woman with longstanding mental retardation, congenital heart disease, and a seizure disorder. She collapsed at the long term care facility with respiratory and cardiac failure which became progressively worse and she expired. An additional finding was the presence of scattered non-neuritic senile plaques in the temporal lobe but lacking additional changes expected in a compelling case of Alzheimer disease. I realize that this patient had a complex clinical picture, however, the long history of mental retardation and limited pathology of Alzheimer disease and seizure-related histopathology seems unlikely to have produced a diffusely small (700 gram) microcephalic brain.
