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Washington University Experience | INFECTION | Viruses | PML (JC Virus) | PML - IRIS | 2F1 PML & IRIS (Case 2) JC ISH whole mount copy
Immunohistochemical staining for SV40, which cross-reacts with the JC virus actually causing PML, demonstrates the presence of JC virus around the margin of the active zone (arrows) surrounding the demyelinated central zone (anti-SV40 IHC)