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Washington University Experience | INFECTION | Viruses | PML (JC Virus) | PML - IRIS | 2F2 PML & IRIS (Case 2) JC ISH
2F2,3 Higher magnification of the active demyelinative margin shows enlarged round cells, most consistent with infected oligodendroglia (SV40 IHC). Two infected oligodendroglia (arrows, #2F3) may represent involvement of satelliting oligodendroglial cells.