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Washington University Experience | INFECTION | Viruses | PML (JC Virus) | PML - Microscopic Pathology | 11H2 PML (Case 11) SV40 40X
An SV40 stain which cross reacts with JC virus is positive in many cells with small, medium, and large nuclei. Typically SV40 immunoreactivity is not as strong in astrocytes (which are not productively infected even though they are infected and contain the viral genome) as are infected oligodendroglia.