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Washington University Experience | INFECTION | Viruses | PML (JC Virus) | PML - Neurosarcoid vs PML Case | 2E4 PML (Case 1) SV40 60X 1 copy
2E3,4 In the astrocyte rich area swollen astrocytes (arrows, 2E3) have very little SV40 staining in their nuclei in comparison to oligodendroglia (arrowhead, 2E3). Other astrocytes are identified by their pale swollen cell bodies (arrowhead, 2E4). It is thought that astrocytes do not generate large amounts of JC protein as they are not productively infected in comparison to oligodendroglia (SV40 IHC)
