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Washington University Experience | INFECTION | Viruses | West Nile Virus | 7A1 Myelitis, West Nile Virus (AANP 2003 Case 6) H&E whole mount

Neuropathology Provided: The brain and spinal cord were grossly unremarkable. Microscopic sections demonstrated widespread microglial infiltrates in the brain and spinal cord and scant mononuclear inflammation in the subarachnoid and perivascular spaces. The microglial infiltrate was most intense in the ventral horns of the spinal cord. A single inflammatory focus was present in one cauda equina nerve root and in the trochlear nerve. The microglial inflammation was present in decreasing intensity in medulla (gray matter more than white matter), cerebellum (especially the dentate nucleus, Purkinje cell layer and the molecular layer), thalamus, the hippocampus and the cerebrum (gray and white matter). Whole mount of the spinal cord in this case is remarkable only for increased numbers of reactive elements

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