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Washington University Experience | METABOLIC | Alcoholism - Overview | Marchiafava-Bignami Disease | 3 Comment -Marchiafava-Bignami Syndrome
It is difficult to unequivocally assign such callosal lesions as just presented to individual diagnostic entities since they may occur secondarily in a variety of entities. Investigators (Starkey et al., Cytotoxic lesions of the corpus callosum that show restricted diffusion: mechanisms, causes and manifestations. Radiographics 2017; 37: 562-576) have described some of these cases under the rubric of "cytotoxic lesions of the corpus callosum, CLOCC") finding them in association with metabolic abnormalities, drug therapy, subarachnoid hemorrhage, malignancy, infections, trauma, and other entities.
