Table of Contents

Washington University Experience | METABOLIC | Neuronal Ceroid Lipofuscinosis (NCL) | 1B9 NCL (Case 1) H&E 4

1B9-11 The cerebellum is particularly relevant to making the diagnosis of adult neuronal ceroid lipofuscinosis. Many neurons (e.g., cerebral cortex, anterior horn, inferior olivary nuclei) accumulate lipopigment normally with age; however, Purkinje neurons are typically spared the age-related accumulation of lipopigment. In these images notice that Purkinje cells accumulate significant amounts of ceroid lipopigment (arrow, 1B10). (H&E)

---