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Washington University Experience | MISCELLANEOUS | Familial erythrophagic lymphohistiocytosis | 2A1 Familial erythrophagic lymphohistiocytosis (AANP 1980, Case 2) 1 H&E X0

Necropsy Findings: The general autopsy showed generalized lymphadenopathy and hepatomegaly. There was Candidiasis of the pharynx, larynx, trachea and esophagus. The dura, basilar vessels, spinal cord, and external examination of the brain were unremarkable. The white matter of the left frontal lobe and both occipital lobes was diffusely granular with a homogeneous gelatinous translucency and depressed cut surface. The cerebral cortex and U-fibers appeared spared. The cerebellar white matter and cortex were similarly involved. Sections of the brainstem were unremarkable. ---- The whole mount of the pons in this case shows hints at a perivascular process (arrows) and involvement of the leptomeninges (arrowhead). (H&E)

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