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Washington University Experience | MISCELLANEOUS | Familial erythrophagic lymphohistiocytosis | 2A7 Familial Erythrophagocytic lymphohistiocytosis (AANP 1980-Case 2) H&E 4

2A7,8 Higher magnification of the parenchymal histiocytic infiltrate. Many histiocytes contain large individual vacuoles (arrows), which some have proposed reflect engulfed partially digestsed red cells. However, these vacuolated histiocytes do not have red cell residua or hemosiderin as do the bone marrow histiocytes. (H&E)

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