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Washington University Experience | MUSCLE | Autophagic myopathy | 6C7 (Case 6) 030 - Copy

Sampling of autophagic vacuoles in this case. (electron micrographs) ---- Interpretation: NM Division: Immune stains in both muscles are consistent with “Inflammatory myopathy with vacuoles, aggregates and mitochondrial pathology” (IM-VAMP), a pathologic set of features often seen with clinical inclusion body myositis syndromes. Pathology includes SMI-31 and LC-3 aggregates, diffuse upregulation of MHC Class I by all muscle fibers, and CD 4 and CD 8 cells scattered and clustered in the endomysium, and focally invading a few muscle fibers

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