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Washington University Experience | MUSCLE | Dermatomyositis | 1B4C Dermatomyositis (Case 1) C5b9 20X3
Small vessels in the perifascicular region demonstrate an increase in C5b-9 staining which reflects formation the Membrane Attack Complex (MAC), a terminal component of the complement system that forms cytotoxic pores causing lysis and cell death. (C5b-9 IHC)
