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Washington University Experience | MUSCLE | Hydroxychloroquine myopathy | 1A1 Hydroxychloroquine Toxicity, Heart (Case 1) EM 019 copy - Copy

1A1-4 Ultrastructural appearance of intracellular osmiophilic, lamellar curvilinear inclusions typical of but not pathognomonic of hydroxychloroquine. ---- 1A1,2 Intracellular examination of individual muscle cells show sarcomeric actin and myosin filaments, numerous mitochondria and lamellar osmiophilic zebra-bodies (arrows, 1A1), seen at higher magnification in 1A2 (electron micrographs)

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