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Washington University Experience | MUSCLE | Myopathies with Mitochondrial Pathology | 30A1D (Case 30) muscle_019 - Copy

Ultrastructural examination of the muscle shows many fibers with collections, typically subsarcolemmal, of numerous mitochondria. Individual mitochondria were increased in number, mildly enlarged and of abnormal shapes. They contain focal clear areas of pale cristae or matrix. These mitochondria are abnormal and really at the margin of mitochondriopathy and mitochondrial myopathy, but do not reach the marked size, unusual matrix contents, "parking lot" formations of typical mitochondrial myopathy. ---- There is no mitochondrial pathology on SDH or COX. There are no dystrophy-related abnormalities of the surface membrane, muscle fiber cytoplasm or aggregates to suggest a hereditary myopathy.

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