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Washington University Experience | MUSCLE | Myopathies with Mitochondrial Pathology | 35A1(Case 35) EM068 - CopyA

Case 35 History ---- The patient is a 59-year-old woman with a rash, weakness, and elevated CK. Electrodiagnostic testing showed a non-irritable myopathy of the upper limbs. ANA is 1:640. Myopathy autoantibody testing showed TIF-1G and Ro52 antibodies. MHC class I shows diffusely increased sarcolemmal staining and fibers with concurrent sarcoplasmic staining, more prominent in the center of the section. ---- 25A1,2 In these mitochondria cristae are thickened dense and misaligned. (electron micrographs)

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