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Washington University Experience | MUSCLE | Myopathies with Mitochondrial Pathology | 36A4 (Case 36)Cervical Paraspinal_024 - Copy

Paraspinal musclee: A subpopulation of muscle fibers additionally contained autophagosomes, some containing mitochondria but most with smaller granular debris. There were numerous large lipopigment (lipofuscin) granules with clear lipidic and osmiophilic constituents; some of these structures had a curvilinear appearance but those inclusions were rare. Some dilated vacuoles appeared to belong to the T-tubule system. Rare small vessels contained vacuolar and solid cytosomes. In some fibers there were increased amounts of granular debris with admixed tubulovesicular elements. There is no storage material on Sudan or PAS. SDH and cytochrome oxidase show irregular internal architecture in many fibers but no primary mitochondrial pathology.

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