3B3 Cerebroretinal Vasculopathy (CRV, TREX, HERNS, Case 3) N16 H&E 1 | Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL, TREX1 Mutation) | MYELIN (NON-IMMUNE MEDIATED)

Washington University Experience | MYELIN (NON-IMMUNE MEDIATED) | Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL, TREX1 Mutation) | 3B3 Cerebroretinal Vasculopathy (CRV, TREX, HERNS, Case 3) N16 H&E 1

3B3,4 In the two magnifications shown there is loss of white matter with macrophage infiltration, areas of unresolved necrosis, hyalinized and occasionally fibrinoid vessels and dystrophic calcifications (seen better in the close up of 3B4) (H&E)

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Washington University Experience | MYELIN (NON-IMMUNE MEDIATED) | Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL, TREX1 Mutation) | 3B3 Cerebroretinal Vasculopathy (CRV, TREX, HERNS, Case 3) N16 H&E 1