5B5 DNL (Case 5) ALL Rx, MTX local to WM & RAD H&E 2 | Necrotizing Leukoencephalopathy | MYELIN (NON-IMMUNE MEDIATED)

Washington University Experience | MYELIN (NON-IMMUNE MEDIATED) | Necrotizing Leukoencephalopathy | 5B5 DNL (Case 5) ALL Rx, MTX local to WM & RAD H&E 2

Higher magnification of necrotizing lesions preferentially involving the white matter of the left centrum semiovale and consist of vacuolated neuropil, numerous axonal spheroids and calcifications. Surrounding areas contain necrosis (H&E)

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Washington University Experience | MYELIN (NON-IMMUNE MEDIATED) | Necrotizing Leukoencephalopathy | 5B5 DNL (Case 5) ALL Rx, MTX local to WM & RAD H&E 2