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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 14B1 PA, CR in nl (Case 14) ACTH 1.jpg
14B1-5 Islands of entrapped normal pituitary acini are also seen. ACTH stains cells in the non-neoplastic acini which show the change in neurosecretory granule distribution caused by Crooke’s hyaline change, some of which have massive perinuclear accumulation of keratin in non-neoplastic ACTH containing cells which are highlighted by ACTH immunoreactivity. (ACTH IHC)
