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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 21A Pituitary Adenoma (Case 21) H&E

Case 21 History ---- [60yo female with Cushing disease, s/p hypophysectomy (2006) and bilateral adrenalectomy (2008), now (2012) with high FDG focus on brain PET scan.] ---- 21A This is a cellular neoplasm organized in trabeculae and a pseudopapillary pattern. The individual tumor cells are monotonous with abundant amphophilic cytoplasm and round to oval nuclei with "salt-and-pepper" chromatin. No necrosis is identified. Mitoses are hard to find. Ki-67 shows a proliferation index up to 2.7%.

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