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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 8C4 PA CR (Case 8) CAM5.2 40X CHC
CAM5.2 shows intense circumferential perinuclear staining in a subpopulation of tumor cells, confirming the presence of Crooke's hyaline in approximately 20% of the tumor cells. (CAM5.2 IHC) ---- Not shown: The proliferation marker Ki-67 shows an elevated maximal proliferation index of 9%. ---- Extensive deposition of Crooke's hyaline and elevated proliferation may be indicative of more aggressive behavior.
