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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Corticotroph | 9B2 PA CR (Case 9)H&E 4.jpg
9B2,3 Appearing in sheets, most of the tumor cells are polygonal or epithelioid with open coarsely speckled chromatin, prominent nucleoli, and moderate amounts of eosinophilic to amphophilic cytoplasm. Occasional groups of cells and single cells show large atypical nuclei. Additionally, many tumor cells exhibit a perinuclear cytoplasmic ring of pale eosinophilic hyalinized material, consistent with Crooke's hyaline change. Mitotic figures are rare.
