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Washington University Experience | NEOPLASM (SELLAR) | Pituitary Adenoma - Pituitary Neuroendocrine Neoplasm | Somatotroph | 3C3 Pituitary adenoma, GH (Case 3) panCK 5.jpg
These spherical perinuclear cytoplasmic inclusions are positive for pan-cytokeratin, consistent with "fibrous bodies." ---- Not shown: Reactivity for the proliferation marker Ki67 ranged focally up to 3.7%. Reactivity for p53 shows nuclear reactivity ranging from weak to strong in a subset of cells. ---- Comment: Given the laboratory finding of elevated serum GH and IGF-1 and the histological/immunohistochemical observation of growth hormone and fibrous bodies, this tumor is consistent with a somatotroph adenoma.
