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Washington University Experience | NEOPLASMS (EMBRYONAL) | ATRT - Atypical Teratoid Rhabdoid Tumor | 18D ATRT (Case 18) CAM5.2 20X
Tumor cells are not immunoreactive for CAM5.2. ---- Not shown: Chromogranin-A highlights only rare dot-like positivity in the tumor cells. while they are negative for SOX10, CD3, and CD20. CD3 highlights the background T-cells, while CAM5.2 stains the sinonasal epithelium. ---- Comment: Targeted next-generation sequencing in this case (FoundationOne CDx) showed a splice site defect in SMARCB1. A DNA methylation-base tumor classification study of this patients tumor at the NIH showed an Atypical teratoid/rhabdoid tumor – MYC-subtype. These tumors are relatively rare in adults with limited number of cases reported in the literature. Nevertheless, published reports have shown their high predilection in middle-aged women, and frequent clustering with AT/RT-MYC subgroup by DNA methylation analysis.
