Table of Contents
Washington University Experience | NEOPLASMS (EMBRYONAL) | Medulloblastoma, Histologically Defined | Large cell-Anaplastic (LCA) | 10F3 Medullo w LCA (Case 10) b-catenin 4
Beta-catenin shows both nuclear and cytoplasmic localization. ---- Not shown: Baf47 (INI-1) is retained within the nucleus. ---- Comment:
The morphological and immunohistochemical features of this tumor are most consistent with a LC/A medulloblastoma (WHO Grade IV). The nuclear expression of Beta-catenin as well as the lack of C-Myc or N-Myc amplification are favorable prognostic indicators. Though a high percentage of medulloblastomas demonstrate isochromosome 17q, this aberration was not present in this case.
