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Washington University Experience | NEOPLASMS (EMBRYONAL) | Medulloblastoma, Histologically Defined | Large cell-Anaplastic (LCA) | 2F3 MB LCA (Case 2) 17 - Copy
In this particular case, there were polysomies (gains) of chromosomes 2 (2F1), 8 (2F2) and 17. Additionally however, there was a relative gain of the NF1 gene on 17q, consistent with the presence of isochromosome 17q. ---- Not shown: The INI-1 (BAF47) stain shows retained nuclear expression. ---- Comment: The morphologic and immunohistochemical features are consistent with the diagnosis of medulloblastoma with focal large cell/anaplastic features, WHO grade IV. The large cell/anaplastic features are based on the increased degree of nuclear pleomorphism, prominent nucleoli and cell wrapping.
