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Washington University Experience | NEOPLASMS (GLIAL) | Astrocytoma, IDH-mutant, WHO Grade 4 | 1E IDHmut Astro Gr4 (Case 1) GFAP 3.jpg
Glial fibrillary acidic protein (GFAP) is seen in tumor cells, including those with gemistocytic morphology. ---- Not shown: Immunostaining for synaptophysin indicates that the 'small blue cell'-like areas identified by H&E do not represent a primitive neuronal component. ---- FISH testing showed loss of 10q/monosomy 10 and was negative for EGFR gene amplification
