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Washington University Experience | NEOPLASMS (GLIAL) | Diffuse midline glioma, H3 K27-altered | 14A0 Case 14 History
Case 14 History ---- The patient was a 12 year old Cambodian male with history of “anaplastic oligodendroglioma” diagnosed in 2/89 after presenting with headaches and right-sided weakness after a fall. The tumor was initially resected in 2/89 at CHOP. The patient was begun on chemotherapy in 3/89; this was complicated by chronic renal failure. His chemotherapy ended in 3/90. Subsequent to a move he was admitted to SLCH with complaints of increasing right-sided weakness and difficulty speaking. A head CT was suggestive of regrowth of the tumor; this was confirmed by a subsequent PET scan. The patient underwent re-resection of the tumor in 8/1990. The histologic sections showed glioblastoma. A subsequent head CT scan showed residual tumor in the posterior fossa and mesencephalon. As the patient was considered incurable, no further plans for surgery were made. He began chemotherapy with Ifosfamide. The patient was re-admitted on 9/6/90 for treatment of generalized seizures and E. coli sepsis. He developed increased seizure activity, which occurred intermittently throughout the night. A short time after discharge to home he had a few agonal breaths and suffered a respiratory arrest.
