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Washington University Experience | NEOPLASMS (GLIAL) | Diffuse midline glioma, H3 K27-altered | 1A0 Case 1 History
Case 1 History ---- The patient was a 12-year-old female who initially presented in December of 2016 with progressively worsening headaches, diplopia, bidirectional end-gaze nystagmus, and left facial droop. Brain MRI at that time showed a mass concerning for pontine glioma extending into the right cerebellar peduncle with hydrocephalus which was shunted. She was started on outpatient radiation therapy, at the end of which her condition had worsened. She was wheelchair-bound at this time due to severe gait instability, and her mother had indicated that she would soon be beginning Nimotuzumab, an anti-EGFR monoclonal antibody that received FDA orphan drug status. In January 2018, she arrived in the ER with sudden shortness of breath, requiring bag mask ventilation. Her cancer treatment had been discontinued two days prior. Given her impending respiratory failure, her mother requested discharge so that she could die peacefully at home.
