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Washington University Experience | NEOPLASMS (GLIAL) | Diffuse midline glioma, H3 K27-altered | 9A0 Case 9 History
Case 9 History ---- This was an 8 year old male being evaluated for increased neurological involvement by tumor including decreased mental status, increase in cranial nerve signs, cord signs, question of seizure activity, appearance of rash and incontinence. In July 1974 the patient was diagnosed as having a brain stem tumor, which was treated without tissue diagnosis, with radiation therapy. He subsequently progressively deteriorated with evidence of rapid spread of tumor in the CNS. He was re-admitted in January 1975 for evaluation and found to have bilateral subfrontal lesions, as well as lumbosacral cord. He was placed on Decadron, Procarbazine, Thorazine and followed. Since then he has become bedridden. The day PTA he developed severe bilateral frontal headaches and became much less responsive. Speech became unintelligible. Urinary and fecal incontinence were noted during this time. Various cranial nerves were asymmetrically dysfunctional. There was nystagmus in all fields of gaze. There was decreased gag bilaterally and he was unable to swallow. He was made comfort care and passed away.
