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Washington University Experience | NEOPLASMS (GLIAL) | Ependymoma, clear cell | 5A6 Ependymoma, clear cell (AANP 2005 Case 10B) H&E 40X
Clear cells are well seen in these tumors, a pattern often seen as a focal change in ependymomas, but tumors composed primarily of these cells (clear cell ependymoma) are rare. There were zones of necrosis in the tumor, but no palisading necrosis. ---- Other immunohistochemical studies (not shown): Tumor cells were strongly positive for GFAP on IHC, and occasional cells were also positive for EMA. The Ki-67 labeling index was 3%. From the conference presenter: The differential diagnosis includes metastatic clear cell tumors, hemangioblastoma, neurocytoma and oligodendroglioma. ---- Tumors of this sort infrequently cross the midline. They are most commonly supratentorial, and they may have aggressive behavior. As with this tumor, clear cell ependymomas usually have sharp borders on histological examination
