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Washington University Experience | NEOPLASMS (GLIAL) | Ependymoma, myxopapillary | 7H Case 7 Denoluement
Case 7H Denouement This histological/immunohistochemical pattern is consistent with clinically residual/recurrent myxopapillary ependymoma, with progression to anaplasia and aggressive growth. Histological slides from this patient's previous resection specimen were reviewed during evaluation of this current specimen, and we consider the previous assessment and diagnosis to have been correct. The vast majority of myxopapillary ependymomas are well-circumscribed lesions with low proliferation/mitotic index. When these tumors cannot be completely resected, radiation therapy has been demonstrated to reduce the incidence of 10-year local progression and 10-year survival significantly (Akyurek et al, PMID: 16648988). In rare cases such as this one, progression can occur.
