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Washington University Experience | NEOPLASMS (GLIAL) | Ependymoma - Microscopic | 17A1 Ependymoma, anaplastic (Case 17) H&E 7
Case 17 History ---- The patient was a 60-year-old man who developed confusion, behavior changes and hand numbness. MRI from 11/23 showed a 4.7 cm ring enhancing left parietooccipital mass. Operative procedure: Left parietooccipital craniotomy for tumor. ----
17A1-3 Sections of the resected parieto-occipital lesion show a neoplasm with multifocal tumor necrosis, including areas suspicious for pseudopalisading necrosis, and microvascular proliferation. Tumor cells appear in highly cellular sheets separated by hyalinized vessels with a suggestion of perivascular sparing. The growth pattern is largely solid with a sharp junction between the tumor and adjacent brain, although an infiltrative pattern is also present focally. Cytologically, neoplastic cells show high nucleus to cytoplasm ratio, moderate pleomorphism and evenly distributed chromatin without prominent nucleoli. Mitoses are easily identified.
