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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, adenoid pattern | 19V2 GBM with Adenoid (Case 19) A3 NF 20X
The islands do not contain neurofilament immunoreactive elements, staining neither tumor cells or infiltrating them. (NF IHC) ---- Comment: The collective findings are consistent with a diagnosis of glioblastoma with adenoid features, IDH1 p.R132H-negative by immunohistochemistry, CNS WHO grade 4. Fluorescence in situ hybridization studies are positive for monosomy10/homozygous deletion of PTEN and polysomy of chromosome 7, but fail to show EGFR gene amplification or homozygous deletion of CDKN2A. MGMT promoter methylation is absent
