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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, adenoid pattern | 4A1 Glioblastoma, adenoid (Case 4) H&E 4X
Case 4 History ---- The patient is a 70 year old man who has had a personality change over four weeks and developed a shuffling gate, facial drooping on the right side of his face and trouble finding words. Head CT showed a large, contrast enhancing mass in the left frontal lobe posteriorly. Clinical diagnosis: Left frontal lobe tumor. Operative procedure: Craniotomy for resection of tumor. ---- 4A1-3 Sections of the mass showed a glioblastoma multiforme with the histologic features of a glioblastoma, adenoid pattern. In these areas there is extensive necrosis within which are perivascular islands of hyperchromatic, epithelioid cells that radiate out from the vasculature. In foci these cells form sheets and nests. In the necrotic areas ghosts of neoplastic cells can be seen. There are also areas of myxoid appearing degeneration. In other areas the tumor has the typical appearance of an astrocytic neoplasm with marked hypercellularity, pleomorphism, vascular proliferation and diffuse infiltration of the surrounding brain parenchyma. (H&E)
