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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, adenoid pattern | 6A3 GBM, Adenoid Features (Case 6) H&E 1

The tumor has both adenoid and spindled (sarcomatoid) differentiation. Moderate to marked pleomorphism, frequent mitoses including atypical forms, prominent endothelial cell hyperplasia, large areas of tumor necrosis including several foci of pseudopalisading necrosis were present. There is marked infiltration of the adjacent cerebral cortex including marked satellitosis and extensive subpial spread.

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