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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, adenoid pattern | 7A3 GBM, Adenoid Features (Case 7) H&E 1

In many areas, the tumor was quite organized in its architecture with nests and ribbons of cells separated by a myxoid stroma. This imparts an adenoid appearance to the tumor. Recognition of this tumor as GBM rather than a metastatic tumor was aided by the presence of areas consisting of cells with more abundant cytoplasm and disorderly arrangement typical of GBM, i.e., with vascular proliferation and areas of necrosis. ---- Immunohistochemistry (not shown): Immunoperoxidase stains show that the tumor was positive for S100 and GFAP. Tumor cells did not stain with antibodies to cytokeratin or neuron specific enolase.

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