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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, epithelioid | 1G GBM, Epithelioid (Case 1) CAM5.2 1
IHCs show patchy reactivity for EMA, and no reactivity for PR or CAM5.2 in the tumor cells. (EMA IHC). ---- Additional studies (not shown): The tumor exhibited no reactivity for the mutant form of IDH1 (R132H). Nuclear reactivity for ATRX was retained in most of the tumor cells. FISH analysis revealed loss of 10q, 14q, and 22q in the tumor cells, without 1p36 deletion or EGFR gene amplification. ---- Analysis by Foundation One Next Generation Sequencing (NGS) identified genetic alterations in BRAF V600E and TP53 R181C and confirmed no alterations in EGFR, IDH1 and PDGFRA. MGMT Promoter Methylation was absent.
