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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, epithelioid | 4E GBM w Epithelioid Features (Case 4) CD68 3.jpg
There was a suspicion that some of the large tumor cells might represent granular GBM and, as a result, a CD68 immunostain was performed. Numerous macrophages were identified but only rare tumor cells were stained. (CD68 IHC) ---- Additional studies: MGMT promoter methylation was not detected. ---- FISH studies were performed in which EGFR amplification was positive but there was no evidence for ROS1, RET, MLL and ALK gene rearrangement. ---- Genomic sequencing using a Comprehensive Cancer Set failed to identify any clinically significant variants.
