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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, primitive neuronal component | 17E1 GBM vs (Case 17) 1 Ki67 whole mount A

17E The nodular pattern of Ki-67 immunoreactivity is strongly positive in primitive nests of tumor cells. ---- Ancillary studies (not shown): FISH showed polysomies (gains) of chromosomes 7, 8, and 10, in some instances with high copy numbers noted. Focal regions suggesting amplification of CMYC were noted (22% of the 200 interphase nuclei scored). No amplification of EGFR or deletion of 10q were observed.

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