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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, primitive neuronal component | 3D2 GBM with PNET features (Case 3) Area A Ki67 20X.jpg
The primitive neuronal complement shows marked proliferative activity (Ki67 IHC)
Ancillary studies (not shown):
IDH1 (R132H) is negative in the tumor cells.
A p53 immunostain shows rare cells with very weak staining.
MGMT (O(6)-methylguanine-DNA methyltransferase) gene methylation was not detected.
Genetic sequence of a set of cancer genes related to CNS neoplasms examined by molecular analysis shows TERT and TP53 mutations.
