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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, primitive neuronal component | 4E2 GBM with PNET features (Case 4) p53 6.jpg
Immunohistochemically stained sections show strong reactivity for p53 in >95% of PNC-like tumor cell nuclei, and in ~70% of GBM-like nuclei. ---- Ancillary studies (not shown): Reactivity for chromogranin-A does not clearly stain any tumor cells. Reactivity for neurofilament (NF) reveals only rare entrapped axons within the dense PNC-like tissue, consistent with a relatively solid growth pattern in these areas. There is no reactivity for IDH1, an antibody specific for the R132H variant of the isocitrate dehydrogenase 1 protein. ---- FISH studies showed no MYC amplifications; however, EGFR amplification and isolated 19q deletion were observed. ---- MGMT (O(6)-methylguanine-DNA methyltransferase) gene methylation was not detected.
