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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, small cell type | 11A1 GBM, small cell features (Case 11) H&E 1.jpg
Case 11 History ---- The patient was a 51 year old woman with a 2 week history of falling, leaning to the left side, and headaches. ---- 11A1-3 Sections reveal a highly cellular infiltrative glial neoplasm with both cortical and white matter involvement. There is mild nuclear pleomorphism, with the majority of tumor nuclei being oval with mild hyperchromasia and scattered clear perinuclear halos. In some areas, there is a prominent spongioblastic pattern, consisting of rhythmic palisades of tumor nuclei. The mitotic index is brisk and there are foci of both endothelial hyperplasia and pseudopalisading necrosis. The morphologic features are consistent with the diagnosis of glioblastoma with small cell features, WHO grade IV. However, given the morphologic overlap between this entity and high grade oligodendroglial neoplasms, genetic studies were pursued.
