Table of Contents

Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, small cell type | 14A2 Glioblastoma, Small Cell (Case 14) H&E 4

This is a markedly cellular infiltrative glial neoplasm. Calcifications are prevalent, and there are areas with delicate, geometrically branching capillary networks. There is nuclear pleomorphism, with the majority of tumor nuclei appearing oval with mild hyperchromasia and minimal discernible cytoplasm. ---- Ancillary Procedures (not shown): Tumor cells were GFAP immunoreactive. ---- FISH studies showed polysomy (gain) of chromosomes 1 and 19 are observed but not 1p/19q codeletion. Deletion of chromosome 10q is present; however, amplification of the EGFR locus is not identified. Although not specific, this genetic pattern is consistent with the diagnosis of glioblastoma with small cell features.

---