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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, small cell type | 17B GBM, small cell type (Case 17) EGFR

17B FISH showed high level EGFR gene amplification and loss of 10q (PTEN gene). FISH for 1p and 19q was non-informative; however, co-deletion of 1p and 19q would be very unlikely given the other cytogenetic abnormalities which are present. ---- Ancillary workup: There is no immunoreactivity for mutant IDH1 (p.R132H). There is retention of ATRX in nuclei and p53 shows moderate staining in scattered nuclei. Methylation of the MGMT (O(6)-methylguanine-DNA methyltransferase) gene was not detected using methylation specific PCR technologies.

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