Table of Contents

Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma, small cell type | 19B2 GBM, small cell variant (Case 19) EGFR - 1

There was high-level EGFR gene amplification in 100% of the 200 interphase nuclei examined. ---- Ancillary studies (not shown): An immunostain for the mutant IDH1 protein (p.R132H) was negative. Methylation of the MGMT (O(6)-methylguanine-DNA methyltransferase) gene was detected using methylation specific PCR technologies. ---- Overall, given the predominance of small cells with minimal cytoplasm, bland chromatin, and a brisk mitotic index, this tumor is best characterized as a small cell glioblastoma, WHO grade IV.

---