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Washington University Experience | NEOPLASMS (GLIAL) | Glioblastoma - Gross Pathology | 17A0 Case 17 History
Case 17 History ---- This patient was a 53 year male who was diagnosed with a GBM in 2/96 surgically resected. Unfortunately, his post-operative course was complicated by wound infection with Enterobacter aerogenes. This led to a resection of the flap which was then treated with a prolonged course of antibiotics with resolution of inflammatory signs. The patient recovered and underwent radiation therapy from 3/18 - 5/14/96. He transferred to the University of Washington in Seattle in 8/1996. He had placement of iodine 125 radioactive seeds with further debridement. He had a subsequent wound infection, again Enterobacter aerogenes. His condition continued to deteriorate and he was transferred back to BH in 9/96. His course was complicated by generalized tonic/clonic seizures and the discovery of a new lesion in the left temporal lobe consistent with metastasis in 1/97. Treatment included a glial "vaccine" without improvement. He was also treated with hyperidin, a protein kinase C inhibitor. He had spastic bilateral hemiparesis left greater than right and cortical left sensory deficits. The patient also had declining cognitive function. At the end of July 1997 he was found unresponsive, pulseless and without respirations, with negative corneal and doll's eye reflex and was pronounced dead after a course lasting 16 months.
