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Washington University Experience | NEOPLASMS (GLIAL) | Gliosarcoma | 20B Gliosarcoma (Case 20) Retic 10X
A reticulin stain shows increased reticulin content, consistent with a gliosarcomatous component. GFAP is positive in a subset of tumor cells, but is negative in large areas of tumor, again consistent with a gliosarcomatous component. Overall, given the presence of a prominent spindled component in this newly resected material which shows patches of reticulin-rich/GFAP-poor tumor, we favored the diagnosis of gliosarcoma, which has arisen from a glioblastoma with an oligodendroglioma component.
